{"id":1209,"date":"2012-08-03T19:12:29","date_gmt":"2012-08-03T17:12:29","guid":{"rendered":"http:\/\/viscontitoscoalda.com\/?p=1209"},"modified":"2012-08-03T19:12:29","modified_gmt":"2012-08-03T17:12:29","slug":"stefano-pluchino","status":"publish","type":"post","link":"https:\/\/viscontitoscoalda.com\/index.php\/2012\/08\/03\/stefano-pluchino\/","title":{"rendered":"Stefano Pluchino  :-) !!!"},"content":{"rendered":"<p><strong>Stem cell therapy as a treatment for MS<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/erc.europa.eu\/sites\/default\/files\/content\/success_stories\/sem.jpg\" alt=\"\" width=\"100\" height=\"100\" \/>This  project looks at stem cells&#8217; potential as a treatment for MS. Rather  than approach stem cells as a replacement for lost or damaged cells, the  research team focuses on the ability of neural stem cells\/ precursor  cells (NPCs) to repair a damaged nervous system. Scientists know very  little about how NPCs work. Dr Pluchino examines the ramifications of a  novel inter-cellular communication mechanism, in which cell membranes  (membrane vesicles, or MVs) are passed from donor to recipient cells.  Understanding how this communication occurs will allow the team to  identify both its molecular makeup and its therapeutic benefits. Using  computational analysis, bioinformatics techniques and rodent models,  this project hopes to determine how stem cell behaviour can be  translated into treatments for neurological disorders.<\/p>\n<p><strong>Grantee<\/strong>: Dr Stefano Pluchino<br \/>\n<strong>Host Institution<a title=\"Legal entity established in an EU Member State or in one of the Associated Countries under the national law of its place of establishment. The Legal entity could also be an international European interest organisation or the Commission's Joint Research Centre. It is the institution that engages and hosts the Principal Investigator.\" href=\"http:\/\/erc.europa.eu\/glossary\/term\/276\"><img decoding=\"async\" src=\"http:\/\/erc.europa.eu\/sites\/all\/themes\/erc\/images\/gloss.png\" alt=\"\" \/><\/a><\/strong>: University of Cambridge (UK)<br \/>\n<strong>ERC Project<\/strong>: Secreted membrane vesicles: role in the therapeutic plasticity of neural Stem cells (SEM_SEM)<br \/>\n<strong>ERC Call<\/strong>: Starting Grant 2010<br \/>\n<strong>ERC Funding<\/strong>: \u20ac 1.5 million for five years<\/p>\n<p><strong>Links <\/strong><br \/>\n<a href=\"http:\/\/www.neuroscience.cam.ac.uk\/directory\/profile.php?pluchino\" target=\"_blank\">Researcher&#8217;s institutional page<\/a><\/p>\n<p>Th\u00e9rapie par cellules souches pour le traitement de la SP<\/p>\n<p>Ce projet se penche sur le potentiel des cellules souches pour le traitement de la SEP. Plut\u00f4t que de cellules souches approche en remplacement des cellules perdues ou endommag\u00e9es, l&#8217;\u00e9quipe de recherche met l&#8217;accent sur la capacit\u00e9 des cellules souches neurales \/ cellules pr\u00e9curseurs (PNJ) pour r\u00e9parer un syst\u00e8me nerveux endommag\u00e9. Les scientifiques savent tr\u00e8s peu de choses sur la fa\u00e7on dont les PNJ travailler. Dr Pluchino examine les ramifications d&#8217;un m\u00e9canisme de communication inter-cellulaire roman, dans les membranes cellulaires cui (v\u00e9sicules membranaires, ou MVS) sont transmis du donneur des cellules receveuses. Comprendre comment cette communication se produit permettra \u00e0 l&#8217;\u00e9quipe d&#8217;identifier deux mol\u00e9culaire sa composition et ses bienfaits th\u00e9rapeutiques. En utilisant l&#8217;analyse informatique, les techniques de bio-informatique et des mod\u00e8les de rongeurs, ce projet vise \u00e0 d\u00e9terminer comment le comportement des cellules souches peut \u00eatre traduit en traitements pour les troubles neurologiques.<\/p>\n<p>B\u00e9n\u00e9ficiaire: Dr Stefano Pluchino<br \/>\nInstitution d&#8217;accueil: Universit\u00e9 de Cambridge (Royaume-Uni)<br \/>\nERC projet: v\u00e9sicules membranaires s\u00e9cr\u00e9t\u00e9es: r\u00f4le dans la plasticit\u00e9 th\u00e9rapeutique des cellules souches neurales (SEM_SEM)<br \/>\nAppel ERC: Starting Grant 2010<\/p>\n<p>Terapia con cellule staminali come trattamento per MS<\/p>\n<p>Questo progetto guarda al potenziale di cellule staminali &#8220;come trattamento per la SM. Piuttosto che le cellule staminali di avvicinamento, in sostituzione delle cellule perse o danneggiate, il team di ricerca si concentra sulla capacit\u00e0 delle cellule staminali neurali \/ cellule precursori (NPC) per riparare un sistema nervoso danneggiato. Gli scienziati sanno molto poco su come funzionano i PNG. Dott. Pluchino ha esaminato le conseguenze di un nuovo inter-cellulare meccanismo di comunicazione, in cui le membrane delle cellule (vescicole di membrana, o MVS) sono, dal donatore al ricevente cellule Passed. Capire come questa comunicazione permetter\u00e0 al team di verifica per individuare sia composizione molecolare delle TIC e dei suoi benefici terapeutici. Usando l&#8217;analisi computazionale, tecniche di bioinformatica e modelli di roditori, il progetto spera di determinare in che modo il comportamento delle cellule staminali pu\u00f2 essere tradotto in trattamenti per le malattie neurologiche.<\/p>\n<p>Concessionario: Dr Stefano Pluchino<br \/>\nIstituto ospitante: Universit\u00e0 di Cambridge (UK)<br \/>\nERC Progetto: vescicole di membrana secrete: ruolo nella plasticit\u00e0 terapeutica delle cellule staminali neurali (SEM_SEM)<br \/>\nERC Call: A partire Grant 2010<br \/>\nERC finanziamento: \u20ac 1.500.000 per cinque anni<\/p>\n<p>Links<br \/>\nPagina istituzionale dei ricercatori<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Stem cell therapy as a treatment for MS This project looks at stem cells&#8217; potential as a treatment for MS. Rather than approach stem cells as a replacement for lost or damaged cells, the research team focuses on the ability of neural stem cells\/ precursor cells (NPCs) to repair a damaged nervous system. Scientists know &hellip; <a href=\"https:\/\/viscontitoscoalda.com\/index.php\/2012\/08\/03\/stefano-pluchino\/\" class=\"more-link\">Continua a leggere <span class=\"screen-reader-text\">Stefano Pluchino  \ud83d\ude42 !!!<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31,33],"tags":[309,323],"class_list":["post-1209","post","type-post","status-publish","format-standard","hentry","category-scienza-ricerca-e-dintorni","category-sclerosi-multipla-e-dintorni","tag-stefano-pluchino","tag-treatment-for-ms"],"_links":{"self":[{"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/posts\/1209","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/comments?post=1209"}],"version-history":[{"count":0,"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/posts\/1209\/revisions"}],"wp:attachment":[{"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/media?parent=1209"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/categories?post=1209"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/tags?post=1209"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}