{"id":1327,"date":"2013-02-02T20:54:39","date_gmt":"2013-02-02T19:54:39","guid":{"rendered":"http:\/\/viscontitoscoalda.com\/?p=1327"},"modified":"2013-02-02T20:54:39","modified_gmt":"2013-02-02T19:54:39","slug":"1327","status":"publish","type":"post","link":"https:\/\/viscontitoscoalda.com\/index.php\/2013\/02\/02\/1327\/","title":{"rendered":"Farmaci cannabinoidi e trattamento sintomatico del dolore e spasticit\u00e0…"},"content":{"rendered":"

Nessun effetto terapeutico. Sbagliato illudere i malati<\/a><\/p>\n

http:\/\/www.avvenire.it\/Cronaca\/Pagine\/nessuna-effetto-terapeutica.aspx<\/a><\/p>\n

Ho letto una rivolta tumultuosa online, dopo l’inserimento di questa pagina in internet fatta dall’autore dell’articolo, concordando che sicuramente \u00e8 vero che non si possono illudere gli ammalati di SM, per una guarigione, ma con questo prodotto usato in pratica medica si possono lenire dolori urenti, continui e devastanti.<\/p>\n

E’ vero, non serve illudere le persone con la Sclerosi Multipla, \u00e8 una patologia con la quale convivo da tanti anni, troppi per continuare a stare male, e sono una fra i tanti in attesa del Sativex e la sua introduzione in Italia a scopo terapeutico, a carico del SSN, perch\u00e8 non posso permettermi di spendere 680 euro a confezione!<\/p>\n

Ho voluto avere informazioni maggiori a livello medico,\u00a0 e mi sono rivolta, inviandogli l’articolo postato online, ad uno dei tanti amici “angeli custodi medici ” che mi sono trovata dopo la morte di mio fratello che era un chirurgo,\u00a0 e che ancora in vita mi parlava di questa sostanza cannabinoide, come un domani potesse lenire le sofferenze dolorose dei pazienti con malattie neurodegenerative, tumorali, ecc. utilizzata a scopo farmaceutico. Sono contraria all’uso personale della cannabis e relativa coltivazione, perch\u00e8 sarebbe incentivare abuso, e creare una sorta di alibi ad utilizzare senza controllo questa sostanza, come molte altre psicotrope senza controllo anche per un banale mal di pancia. Diverrebbe una sorta di autorizzazione al fai da te!<\/p>\n

Vorrei invece che il problema venisse affrontato come sta gi\u00e0 accadendo in alcune regioni Italiane,\u00a0 in maniera seria, adottando regole e provvedimenti per favorire questo utilizzo sia di Sativex che Bedrocan, Nabilone ed altri che non sto a citare, presso\u00a0 i centri di cure per il dolore, e di neurologia ed oncologia,\u00a0 a regime SSN, non a carico del paziente, seguendo protocolli, e sempre sotto stretto controllo specialistico.<\/p>\n

Ecco cosa ho ricevuto, da questa “presenza”, che chiamer\u00f2 “Herman”\u00a0 in ricordo di mio fratello Ermanno. Sperando possa aiutare a capire di cosa si parla e perch\u00e8 si sta lottando per avere questo tipo di farmaci.<\/p>\n

“FARMACI CANNABINOIDI E TRATTAMENTO SINTOMATICO DEL DOLORE E DELLA SPASTICITA’ MUSCOLARE”<\/p>\n

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Da anni sono in uso nel nord America e nel nord d’Europa farmaci cannabinoidi per il trattamento sintomatico di disturbi afferenti per lo pi\u00f9 all’area di competenza neurologica.<\/p>\n

In Italia \u00e8 previsto l’uso di sostanza psicotrope ad uso medico con attivit\u00e0 terapeutica dimostrata quali barbiturici, benzodiazepine ed oppiacei.<\/p>\n

Per quel che riguarda i derivati della cannabis nel 2006 il Ministero della Salute, con un’ordinanza, consentiva la importazione di cannabinoidi a scopo terapeutico.<\/p>\n

Attualmente i medesimi non sono presenti su mercato italiano.<\/p>\n

Per ordinare all’estero tali specialit\u00e0 medicinali, occorre seguire la procedura richiesta dall’ art. 2 del D.M. 11.02.1997 (Importazione di specialit\u00e0 medicinali registrate all’estero).<\/p>\n

A questo ultimo si rimanda.<\/p>\n

\n

Il senso ultimo di queste righe vuole essere, nella intenzione di chi scrive, un commento all’articolo apparso su Avvenire del 02.02.2013 dal titolo \u201cNessun effetto terapeutico. Sbagliato illudere i malati\u201d<\/p>\n

\n

Personalmente sono fondamentalmente in accordo con l’autore dell’articolo: sia dove dice che i cannabinoidi non hanno alcun effetto terapeutico sull’andamento della patologia di base sia dove dice che essi agiscono quali sintomatici sulla spasticit\u00e0 muscolare e sul dolore.<\/p>\n

\n

La opinione di chi scrive \u00e8 che si stia facendo un poco edificante uso strumentale circa l’argomento \u201cfarmaci cannabinoidi\u201d.
\nQuesto fa male ai pazienti ed allontana la idea dello sdoganamento delle sostanze in questione quali sostanze ad effetto terapeutico\/sintomatico.<\/p>\n

Non \u00e8 giusto illudere i pazienti: assolutamente concorde!<\/p>\n

Non esiste EBM (\u201cevidence based medicine\u201d ovvero medicina basata sull’evidenza) a favore in un loro effetto terapeutico sulla evoluzione della patologia. Ma \u00e8 altrettanto vero che esistono evidenze circa l’effetto sintomatico della spasticit\u00e0 e del dolore (non solo nei pazienti affetti Sclerosi Multipla, poich\u00e9 la spasticit\u00e0 dolorosa ad esempio nello Stroke o Ictus, si giova comunque del cannabinoide ad uso sintomatico). E ci\u00f2 non \u00e8 poco!<\/p>\n

Il dolore da spasticit\u00e0 muscolare produce sofferenza comunque nei pazienti; non importa (al dolore, alla sofferenza) se chi ne \u00e8 colpito sia di destra o di sinistra. Il dolore fa solo il suo sporco lavoro: causa sofferenza all’essere umano<\/p>\n

\n

I farmaci cannabinoidi sono efficaci nel dolore da spasticit\u00e0 muscolare come \u201csintomatici\u201d mentre non vi \u00e8 alcuna evidenza basata sulla medicina che abbiano un qualche effetto sulla evoluzione della patologia di base.<\/p>\n

Essi possono essere prescritti dal medico di famiglia o dallo specialista ospedaliero. Pertanto sempre e solo sotto controllo medico.<\/p>\n

\n

Poche righe ancora circa il meccanismo d’azione<\/p>\n

Il delta-9-tetraidrocannabinolo (THC) agisce a livello del Sistema Nervoso Centrale (SNC) stimolando il rilascio di dopamina dal nucleus accumbens, provocando nella persona reazioni sia fisiche che psichiche (compreso alcuni effetti collaterali). Il legame dei cannabinoidi ai recettori CB1 causa una inibizione presinaptica del rilascio di vari neurotrasmettitori (in particolare dopamina, NMDA e glutammato), ed una stimolazione delle aree della sostanza grigia periacqueduttale (PAG) e del midollo rostrale ventromediale (RVM), che a loro volta inibiscono le vie nervose ascendenti del dolore.<\/p>\n

\n

\n

A livello del midollo spinale il legame dei cannabinoidi ai recettori CB1 causa una inibizione delle fibre afferenti a livello del corno dorsale, ed a livello periferico il legame dei cannabinoidi con i recettori CB1 e CB2 causa una riduzione della secrezione di vari prostanoidi e citochine proinfiammatorie, la inibizione del segnale doloroso.<\/p>\n

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Bibliografia<\/p>\n

Campbell FA et al. Are cannabinoids an effective and safe treatment option in the manage\u00adment of pain? A qualitative systematic review. BMJ 2001; 323 (7 July): 1-6.<\/p>\n

Clapper JR, Magieri RA, Piomelli D. The endocannabiond system as a target for the treat\u00adment of cannabis dependence. Neuropharmacology 2009; 56 (Suppl 1): 235-243.<\/p>\n

Clapper JR, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, Duranti A, Tontini A, Sanchi\u00adni S, Sciolino NR, Spradley JM, Andrea G Hohmann AG, Calignano AC, Mor M, Tarzia G, Piomelli D. Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nature Neuroscience 13, 1265 – 1270 (2010).<\/p>\n

ClinicalTrials.gov identifier: NCT00397605. University of British Columbia. Cannabinoids in Bipolar Affective Disorder. 2010 http:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT00397605? term=cannabis,+depression&rank=13<\/p>\n

P. Dronabinol effects on weight in patients with HIV infection. AIDS 6:127, 1992.<\/p>\n

Guzm\u00e1n Manuel. Cannabinoids: potential anticancer agents. Nature review. Cancer Volu\u00adme 3. 745-755. October 2003.<\/p>\n

Hazekamp A, Grotenhermen F. Review on clinical studies with cannabis and cannabinoids 2005-2009. Cannabinoids 2010; 5 (special issue):1-21. http:\/\/clinicaltrials.gov\/ct2\/show\/ study\/NCT00397605?term=cannabis,+depression&rank=13<\/p>\n

Iuvone T, Esposito G, De Filippis D, Scuderi C, Steardo L. Cannabidiol: A Promising Drug for Neurodegenerative Disorders? CNS Neuroscience & Therapeutics. Volume 15, Issue 1, pages 65\u201375, 2009.<\/p>\n

Lakhan SE and Rowland M. Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review. BMC Neurology 2009, 9:59 doi:10.1186\/1471- 2377-9-59.<\/p>\n

Leweke FM, Koethe D, Gerth CW, Nolden BM, Schreiber D, H\u00e4nsel A, Neatby MA, Jueli\u00adcher A, Hellmich M,<\/p>\n

Klosterk\u00f6tter J. Cannabidiol as an antipsychotic. A double-blind, controlled clinical trial on cannabidiol vs. amisulpride in acute schizophrenia. Abstract for oral sessions \/ European Psychiatry 2007;22:S14.02.<\/p>\n

Morgan CJA, Curran HV. Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis. The British Journal of Psychiatry (2008) 192, 306\u2013307.<\/p>\n

Muntoni AL, Melis M, Diana M, Electrophysiological effects of cannabinoids in the basal ganglia, 2002.<\/p>\n

Nahas GG. Hashish In Islam 9th To 18th Century. Bull. N.Y. Acad. Med. Vol. 58, No. 9, December 1982.<\/p>\n

O\u2019Shaughnessy WB. On the preparations of the indian hemp, or gunjah (cannabis indica); their effects on the animal system in health, and their utility in the treatment of tetanus and other convulsive diseases. 1839. Trans. of the Med. and Phys. Society of Bengal (1838- 40):421-61.<\/p>\n

Piomelli D, Tarzia G, Duranti A, et al. Pharmachological profile of the selective FAAH inhi\u00adbitor KDS-4103 (URB597). CNS Drug Rev 2006; 12(1) 21-38.<\/p>\n

Plange N, Arend KO, Kaup M, Doehmen B, Adams H, Hendricks S, Cordes A, Huth J, Spon\u00adsel WE, Remky A. Dronabinol and retinal hemodynamics in humans. Am. J. Ophthalmol. 2007;143(1):173-174.<\/p>\n

Price DA, Martinez AA, Seillier A, Koek W, Acosta Y, Fernandez E, Strong R, Lutz B, Mar\u00adsicano G, Roberts JL, Giuffrida A. WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson\u2019s disease. Eur J Neurosci. 2009 Jun;29(11):2177-86.<\/p>\n

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Pryce G, Ahmed Z, Hankey DJR, Jackson SJ, Croxford JL, Pocock JM, Ledent C, Petzold A, Thompson AJ, Giovannoni G, Cuzner ML, Baker D. Cannabinoids inhibit neurodegenera\u00adtion in models of multiple sclerosis. Brain (2003), 126, 2191-2202.<\/p>\n

Pryce G, Baker D. Emerging properties of cannabinoid medicines in management of mul\u00adtiple sclerosis. Trends Neurosci 2005; 28(5): 272-276.<\/p>\n

Romero J, Orgado JM. Cannabinoids and neurodegenerative diseases. CNS Neurol Disord<\/p>\n

Drug Targets. 2009 Dec;8(6):440-50.<\/p>\n

Russo E. Cannabis for migraine treatment: the once and future prescription? An historical and scientific review. Pain. 1998 May;76(1-2):3-8.<\/p>\n

Smith PF. New approaches in the management of spasticity in multiple sclerosis patients: role of cannabinoids. Therapeutics and Clinical Risk Management 2010:6 59\u201363.<\/p>\n

Thaera GM, Wellik KE, Carter JL, Demaerschalk BM, Wingerchuk DM. Do cannabinoids reduce multiple sclerosis-related spasticity? Neurologist. 2009 Nov;15(6):369-71.<\/p>\n

Tomida I, Azuara-Blanco A, House H, Flint M, Pertwee RG, Robson PJ. Effect of Sublingual Application of Cannabinoids on Intraocular Pressure: A Pilot Study. (2006) Journal of Glau\u00adcoma 15(5):349-353.<\/p>\n

Tram\u00e8r MR et al. Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. BMJ, 323 (2001):16-24.<\/p>\n

—————————————————–<\/p>\n

<\/p>\n

No therapeutic effect. Wrong to deceive the sick<\/p>\n

I read a tumultuous revolt online, after the inclusion of this page on the Internet by the author of the article, agreeing that it is certainly true that you can not deceive the people suffering from MS, for a cure, but with this product used in practice medicine can relieve pain urenti, continuous and devastating.<\/p>\n

It ‘s true, no need to deceive people with multiple sclerosis, is a disease in which cohabit for many years, too many to continue to get sick, and are one of the many waiting for Sativex and its introduction in Italy for treatment at the expense of the NHS, because I can not afford to spend 680 euro per pack!<\/p>\n

I wanted to have more information on a medical level, and I turned, sending the article posted online, one of the many friends “guardian angels doctors” that I found after the death of my brother who was a surgeon, and that still life was telling me about this cannabinoid substance, such as a painful tomorrow could alleviate the suffering of patients with neurodegenerative diseases, cancer, etc.. used for pharmaceutical purposes. I am against the personal use of cannabis and its cultivation, because it would encourage abuse, and create a sort of excuse to use this control without substance, like many other psychotropic without control even for a simple stomach ache. Become a kind of permission to do it yourself!<\/p>\n

I would rather that the problem was dealt with as is already happening in some Italian regions, in a serious way, adopting rules and measures to promote this use of Sativex is that Bedrocan, Nabilone and others that I will not mention, at care centers for pain, neurology and oncology, at full SSN, not the patient, using protocols, and always under strict control specialist.<\/p>\n

Here’s what I got from this “presence”, which I call “Herman” in memory of my brother Herman. Hoping to help you understand what they are about and why you are struggling to have this type of medication.<\/p>\n

“DRUGS AND CANNABINOIDS symptomatic relief of pain and spasticity ‘MUSCLE”<\/p>\n

For years I have used in North America and northern Europe cannabinoid drugs for the symptomatic treatment of disorders related to the area covered mostly neurological.<\/p>\n

In Italy it is expected the use of psychotropic substances for medical use with demonstrated therapeutic activity such as barbiturates, benzodiazepines and opiates.<\/p>\n

With regard to cannabis derivatives in 2006 the Ministry of Health, by order, allow the import of cannabis for therapeutic purposes.<\/p>\n

Currently, the same are not present on the Italian market.<\/p>\n

To order such products abroad, you must follow the procedure required by ‘art. 2 of Ministerial Decree 11\/02\/1997 (Importing medicines that are registered abroad).<\/p>\n

In this last reference is made.<\/p>\n

The ultimate meaning of these lines want to be, in the intention of the writer, a review article published in Avvenire of 02.02.2013 entitled “No therapeutic effect. Wrong to deceive the sick ”<\/p>\n

Personally, I am basically in agreement with the author of the article: it is where it says that cannabinoids have no therapeutic effect on the progress of the underlying disease is where it says that they act as symptomatic on muscle spasticity and pain.<\/p>\n

The writer’s opinion is that it is doing a little uplifting instrumental use about the topic “cannabinoid drugs.”
\nThis is bad for patients and away the idea of \u200b\u200bcustoms clearance of these substances as substances having therapeutic \/ symptomatic.<\/p>\n

It is not right to deceive patients: absolutely agree!<\/p>\n

There EBM (“evidence based medicine” or evidence-based medicine) for a therapeutic effect on the evolution of the disease. But it is equally true that there is evidence for the symptomatic effect of spasticity and pain (not only in patients with multiple sclerosis, for example painful spasticity in stroke or stroke, however, takes advantage of the cannabinoid use symptomatic). And this is no small feat!<\/p>\n

The pain from muscle spasticity leads to suffering patients, however, do not care (pain and suffering) if those affected either the right or left. The pain is only his dirty work: causes suffering to the human<\/p>\n

The cannabinoid drugs are effective in pain from muscle spasticity as “symptomatic” while there is no evidence-based medicine that has some effect on the evolution of the underlying disease.<\/p>\n

They may be prescribed by the family doctor or specialist hospital. Therefore always and only under medical supervision.<\/p>\n

A few lines still about the mechanism of action<\/p>\n

The delta-9-tetrahydrocannabinol (THC) acts in the central nervous system (CNS) stimulating the release of dopamine from the nucleus accumbens, in the person causing both physical and psychological reactions (including some side effects). The binding of the cannabinoid receptor CB1 causes a presynaptic inhibition of the release of various neurotransmitters (in particular dopamine, glutamate and NMDA), and a stimulation of areas in the periaqueductal gray (PAG) and the rostral ventromedial medulla (RVM), which in their Once inhibit ascending pain pathways.<\/p>\n

At the level of the spinal cord to the binding of the cannabinoid CB1 receptors cause an inhibition of the afferent fibers at the level of the dorsal horn, and at the peripheral level of the link with the cannabinoid receptors CB1 and CB2 receptors causes a reduction of the secretion of various prostanoids and proinflammatory cytokines, the inhibition of the pain signal.<\/p>\n

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Aucun effet th\u00e9rapeutique. Tort de tromper les malades<\/p>\n

J’ai lu une ligne r\u00e9volte tumultueuse, apr\u00e8s l’inclusion de cette page sur Internet par l’auteur de l’article, en convenant qu’il est vrai que vous ne pouvez pas tromper les gens atteints de SEP, pour une cure, mais avec ce produit utilis\u00e9 dans la pratique m\u00e9dicament peut soulager la douleur, urenti continue et d\u00e9vastatrice.<\/p>\n

C’est vrai, pas besoin de tromper les gens avec la scl\u00e9rose en plaques est une maladie dans laquelle cohabitent depuis de nombreuses ann\u00e9es, trop nombreux pour continuer \u00e0 tomber malade, et sont l’une de l’attente beaucoup pour le Sativex et son introduction en Italie pour traitement \u00e0 la charge du NHS, parce que je ne peux pas se permettre de d\u00e9penser \u20ac 680 par pack!<\/p>\n

Je voulais avoir plus d’informations sur le plan m\u00e9dical, et je me suis tourn\u00e9, l’envoi de l’article publi\u00e9 en ligne, l’un des nombreux amis “tuteur m\u00e9decins anges” que j’ai trouv\u00e9 apr\u00e8s la mort de mon fr\u00e8re qui \u00e9tait un chirurgien, et qu’il est encore la vie m’a parl\u00e9 de cette substance cannabino\u00efde, comme une douloureuse demain pourrait all\u00e9ger les souffrances des patients atteints de maladies neurod\u00e9g\u00e9n\u00e9ratives, cancers, etc. utilis\u00e9 \u00e0 des fins pharmaceutiques. Je suis contre l’usage personnel de cannabis et sa culture, car cela encouragerait les abus, et de cr\u00e9er une sorte d’excuse pour utiliser ce contr\u00f4le sans substance, comme beaucoup d’autres psychotropes sans contr\u00f4le, m\u00eame pour un mal d’estomac simple. Devenir une sorte de permission de le faire vous-m\u00eame!<\/p>\n

Je pr\u00e9f\u00e9rerais que le probl\u00e8me a \u00e9t\u00e9 trait\u00e9e comme c’est d\u00e9j\u00e0 le cas dans certaines r\u00e9gions italiennes, d’une mani\u00e8re s\u00e9rieuse, en adoptant des r\u00e8gles et des mesures visant \u00e0 promouvoir l’utilisation de cette Sativex est que Bedrocan, nabilone et d’autres que je ne citerai pas, dans les centres de soins pour les la douleur, de la neurologie et en oncologie, au SSN complet, et non le patient, en utilisant des protocoles, et toujours sous un contr\u00f4le strict sp\u00e9cialiste.<\/p>\n

Voici ce que j’ai re\u00e7u de cette \u00abpr\u00e9sence\u00bb, que j’appelle \u00abHerman\u00bb dans la m\u00e9moire de mon fr\u00e8re Herman. Dans l’espoir de vous aider \u00e0 comprendre ce qu’ils sont et pourquoi vous avez du mal \u00e0 avoir ce type de m\u00e9dicament.<\/p>\n

\u00abLes drogues et de secours CANNABINO\u00cfDES symptomatique de la douleur et de la spasticit\u00e9 MUSCLE ‘”<\/p>\n

Pendant des ann\u00e9es j’ai utilis\u00e9 en Am\u00e9rique du Nord et Europe du Nord m\u00e9dicaments cannabino\u00efdes dans le traitement symptomatique des troubles li\u00e9s \u00e0 la zone couverte essentiellement neurologique.<\/p>\n

En Italie, il est pr\u00e9vu l’utilisation de substances psychotropes \u00e0 des fins m\u00e9dicales ayant une activit\u00e9 th\u00e9rapeutique d\u00e9montr\u00e9, comme les barbituriques, les benzodiaz\u00e9pines et les opiac\u00e9s.<\/p>\n

En ce qui concerne les d\u00e9riv\u00e9s du cannabis en 2006, le minist\u00e8re de la Sant\u00e9, par arr\u00eat\u00e9, autoriser l’importation de cannabis \u00e0 des fins th\u00e9rapeutiques.<\/p>\n

\u00c0 l’heure actuelle, les m\u00eames ne sont pas pr\u00e9sents sur le march\u00e9 italien.<\/p>\n

Pour commander ces produits \u00e0 l’\u00e9tranger, vous devez suivre la proc\u00e9dure pr\u00e9vue par l’art. 2 du d\u00e9cret minist\u00e9riel 02\/11\/1997 (Importation de m\u00e9dicaments qui sont immatricul\u00e9s \u00e0 l’\u00e9tranger).<\/p>\n

Dans cette derni\u00e8re r\u00e9f\u00e9rence est faite.<\/p>\n

Le sens ultime de ces lignes voulons \u00eatre, dans l’intention de l’auteur, un article de synth\u00e8se publi\u00e9 en Avvenire du 02.02.2013 intitul\u00e9 \u00abPas d’effet th\u00e9rapeutique. Tort de tromper les malades ”<\/p>\n

Personnellement, je suis fondamentalement d’accord avec l’auteur de l’article: il est o\u00f9 il est dit que les cannabino\u00efdes n’ont aucun effet th\u00e9rapeutique sur la progression de la maladie sous-jacente est o\u00f9 il est dit qu’ils agissent comme symptomatique de la spasticit\u00e9 musculaire et la douleur.<\/p>\n

Avis de l’auteur, c’est qu’il fait un peu \u00e9difiante utilisation instrumentale sur le sujet des \u00abm\u00e9dicaments cannabino\u00efdes.”
\nCe n’est pas bon pour les patients et loin l’id\u00e9e de d\u00e9douanement de ces substances comme des substances dont th\u00e9rapeutique \/ symptomatique.<\/p>\n

Il n’est pas juste pour tromper les patients: absolument d’accord!<\/p>\n

Il EBM (“evidence based medicine” ou de la m\u00e9decine fond\u00e9e sur les preuves) pour un effet th\u00e9rapeutique sur l’\u00e9volution de la maladie. Mais il est \u00e9galement vrai qu’il existe des preuves de l’effet symptomatique de la spasticit\u00e9 et de la douleur (et pas seulement chez les patients atteints de scl\u00e9rose en plaques, par exemple la spasticit\u00e9 douloureuse accident vasculaire c\u00e9r\u00e9bral ou accident vasculaire c\u00e9r\u00e9bral, cependant, prend avantage de l’utilisation des cannabino\u00efdes symptomatique). Et ce n’est pas un mince exploit!<\/p>\n

La douleur de spasticit\u00e9 musculaire conduit \u00e0 la souffrance des patients, cependant, ne se soucient pas (douleur et souffrance) si les personnes touch\u00e9es, soit l’. Droite ou \u00e0 gauche La douleur n’est que son sale boulot: cause de la souffrance de l’humain<\/p>\n

Les m\u00e9dicaments cannabino\u00efdes sont efficaces dans la douleur de spasticit\u00e9 musculaire comme \u00absymptomatiques\u00bb alors qu’il n’y a pas de m\u00e9decine factuelle qui a un effet sur l’\u00e9volution de la maladie sous-jacente.<\/p>\n

Ils peuvent \u00eatre prescrits par le m\u00e9decin de famille ou un h\u00f4pital sp\u00e9cialis\u00e9. Il faut donc toujours et uniquement sous surveillance m\u00e9dicale.<\/p>\n

Quelques lignes encore sur le m\u00e9canisme d’action<\/p>\n

Le delta-9-t\u00e9trahydrocannabinol (THC) agit dans le syst\u00e8me nerveux central (SNC) la stimulation de la lib\u00e9ration de dopamine par le noyau accumbens, en la personne de provoquer des r\u00e9actions physiques et psychologiques (y compris certains effets secondaires). La liaison du r\u00e9cepteur cannabino\u00efde CB1 entra\u00eene une inhibition pr\u00e9synaptique de la lib\u00e9ration de divers neurotransmetteurs (la dopamine particulier, le glutamate et NMDA), et une stimulation des zones dans la grise p\u00e9riaqueducale (PAG) et le rostrale rachidien ventrom\u00e9dian (RVM), qui, dans leur Une fois inhiber voies de la douleur ascendants.<\/p>\n

Au niveau de la moelle \u00e9pini\u00e8re \u00e0 la liaison des r\u00e9cepteurs CB1 des cannabino\u00efdes r\u00e9cepteurs provoquer une inhibition des fibres aff\u00e9rentes au niveau de la corne dorsale, et au niveau p\u00e9riph\u00e9rique de la liaison avec les r\u00e9cepteurs cannabino\u00efdes CB1 et CB2 provoque une diminution de la s\u00e9cr\u00e9tion de prostano\u00efdes diverses et des cytokines pro-inflammatoires, l’inhibition du signal de la douleur.<\/p>\n

\n","protected":false},"excerpt":{"rendered":"

Nessun effetto terapeutico. Sbagliato illudere i malati http:\/\/www.avvenire.it\/Cronaca\/Pagine\/nessuna-effetto-terapeutica.aspx Ho letto una rivolta tumultuosa online, dopo l’inserimento di questa pagina in internet fatta dall’autore dell’articolo, concordando che sicuramente \u00e8 vero che non si possono illudere gli ammalati di SM, per una guarigione, ma con questo prodotto usato in pratica medica si possono lenire dolori urenti, continui … Continua a leggere Farmaci cannabinoidi e trattamento sintomatico del dolore e spasticit\u00e0…<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,7],"tags":[64,79,119,287],"class_list":["post-1327","post","type-post","status-publish","format-standard","hentry","category-bioetica-e-dintorni","category-cannabis-e-sclerosi-multipla","tag-avvenire","tag-cannabis","tag-dolori","tag-sclerosi-multipla"],"_links":{"self":[{"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/posts\/1327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/comments?post=1327"}],"version-history":[{"count":0,"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/posts\/1327\/revisions"}],"wp:attachment":[{"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/media?parent=1327"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/categories?post=1327"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/viscontitoscoalda.com\/index.php\/wp-json\/wp\/v2\/tags?post=1327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}